The immediate type allergic reactions include hay fever, asthma and hives. They are not directly caused by oxidative stress. However, hydrogen water has shown to exert therapeutic effects regardless OH neutralization. Sus efectos se manifiestan porque disminuye la liberación de sustancias del sistema inmune, sustancias implicadas en el desarrollo de los procesos alérgicos.
Research suggest that hydrogen may be effective for a wide variety of allergic diseases, such as asthma, rhinitis , conjunctivitis, hay fever and hives. These allergic reactions are referred to as type I or immediate and they are not caused by oxidative stress. Consequently, the beneficial effect of hydrogen has nothing to do with free radicals neutralization but with its modulating activity of specific signalling pathways.
The preventive effects of hydrogen water on type I allergic reactions have been shown with a mouse model. It was verified that with the use of hydrogen mast cell degranulation decreased due to phosphorylation reduction. This was induced by the antigen FceRI receptors associated to Lyn, thus causing ocasionando a decrease in signal transduction. Consequently, less substances responsible for allergic symptoms were released, such as histamine, leukotrienes, prostaglandins, platelet activating factor, chemotactic factors and cytokines. This mechanism also inhibited NADPH oxidase activity, thus reducing H2O2 production. NADPH oxidase inhibition attenuated the Lyn phosphorylation in mast cells, indicating the presence of a feedforward circuit which enhances allergic response. Therefore, hydroge ninhibits all signalling molecules involved in that circuit.
Serum histamine levels also decreased significantly in mice ingesting hydrogen rich water for 4 weeks, comparing to the ones drinking tap water.
FceRI receptors: E immunoglobulin receptors (IgE), involved in type I allergic processes.