Hydrogen can be administered by inhalation, dissolved in water and using strategies that affect endogenous production of hydrogen. Dissolved in water hydrogen is the most convenient way to provide molecular hydrogen easily and safely.
One of the most common ways to obtain hydrogen water is electrolysis. With this method reduced water, rich in hydrogen, is obtained. The result is water with an alkaline pH, low dissolved oxygen content, high molecular hydrogen content and potential negative redox.
This way to obtain reduced water by electrolysis produces the so-called "active hydrogen" because it has shown to neutralize reactive oxygen species as well as to protect DNA, RNA and proteins from oxidative damage.
Titanium electrodes coated with platinum are best used for electrolysis. They are the ones mostly used in reduced water generators. Hydrogen atoms (active hydrogen) and hydrogen molecules are generated at the cathode, as well as mineral nanoparticles.
The continuous consumption of hydrogen water may have effects even at concentrations of 0.2 ppm (parts per million), because continued exposure to hydrogen can modify the components of blood to a reduced or alkaline state, thus impacting in the oxidative state of the body.
Mysuso and H2-365 provide 1 ppm of dissolved hydrogen. This concentration level is enough to neutralize hydroxyl radicals (·OH) because it has been proven that 0,2 ppm is the minimum concentration requiered to eliminate these free radicals. This correlation is dose dependent up to 0.4 ppm. Above this level the effect is stabilized and does not increase the antioxidant efficiency.
In 1960, hydrogen water was first applied in medicine as a beneficial water. In 1966 the Japanese Ministry of Health admitted that reduced water obtained by electrolysis was effective under conditions of chronic diarrhea, indigestion, abnormal gastrointestinal fermentation and hyperacidity. Devices for domestic use were authorized.