Dermatitis & Skin aging

The skin is one of the organs most affected by oxidative stress caused by UV radiation and aging itself. Consequences: among others, inflammatory phenomena, cancer, immunosuppression, wrinkles and accelerated aging, cellular and structural damage.

Both stains as atopic dermatitis or skin grains are the result of the effect of oxidized substances caused by ROS. According to several studies, spots are originated by the action of ROS in the skin cell layers, in between dermis and epidermis. They cause excessive production of melanin to protect themselves from harmful ROS.


Hydrogen water benefits , including antioxidants and anti-inflammatory effects have been widely demonstrated and there is evidence of their effect in atopic dermatitis, an inflammatory skin disease. In addition , hydrogen water intake or direct and generous application to the skin activates the metabolism of skin cells and slows down stains and pimples.

Direct application of hydrogen water on human skin has shown to reduce the redox potential (ORP ). This is an important finding since healthy skin has reductive features and skin ORP increases as a consequence of oxidative damage resulting from exposure to the sun and of aging as well, by increasing lipid peroxidation. This relationship between redox potential and skin aging has been investigated in detail. It shows that water with reductor effect (antioxidant) reduce skin oxidation. Taking a bath with hydrogen water does not only reduce the ORP of the skin but also improves its elasticity.


Hydrogen water has shown to have benefits against damage induced by UVA radiation on skin cells. A pilot study carried out in models of fibroblasts and keratinocytes showed that those cells treated with hydrogen water, for 3-5 days, synthesized twice the amount of type 1 collagen. Furthermore, the application of hydrogen water prevented cell death and DNA damage and decreased levels of intracellular free radicals. The study also revealed that, in humans, washing with hydrogen water for three months improved wrinkles significantly. Therefore, hydrogen water is recommended for daily skin care in order to eliminate skin damage induced by UVA radiation, to neutralize free radicals, and to foster collagen synthesis.

This is the first study to demonstrate the effect of drinking hydrogen water in atopic dermatitis (AD), a type of inflammatory disease associated with oxidative stress.

Drinking hydrogen water suppresses inflammation related mediators levels such as Th1, Th2 and pro-inflammatory cytokines that are truly involved in the pathogenesis of human DA. In addition, this study provides new insight into the relevance of certain cytokines in AD. Hydrogen water acts as a preventive and therapeutic alternative in the DA.

Case 1: Patient with atopic dermatitis (female, 25yrs) consumed hydrogen-containing water every day for 3 months (330ml, 3 times a day). Test values were compared before and after drinking the water: IgE, lipoperoxide and eosinophile.

By comparing the test results, an evident decline in the values was shown. Also, disappearance of the eczema can be seen on macroscopic observation.


Case 2: Patient with atopic dermatitis received both of the following 2 types of treatments for 2 weeks. Then, appearances of eczema and dermatitis before and after treatment were compared.

  1. Drink hydrogen-containing water (330ml, 3 times a day)
  2. Direct apply hydrogen-containing water (330ml a day)

Volunteer A Age: 34 Genre: Male


Volunteer B Age: 25 Genre: Female


Volunteer C Age: 29 Genre: Female